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Crossword solution:

12 clues for "WISE":

  1. In the know.
  2. Judicious.
  3. Knowing
  4. Madison Avenue suffix
  5. Overworked suffix
  6. Sagacious.
  7. Sage
  8. Sapient.
  9. healthy and wealthy and ___
  10. Informed.
  11. Learned.
  12. Prudent.